A system biology approach to understand functional activity of cell communication systems.
作者： Julio Vera , Olaf Wolkenhauer
DOI: 10.1016/S0091-679X(08)00817-0
关键词: Cell biology 、 Computational biology 、 Biology 、 Functional activity 、 Process (engineering) 、 Cell signaling 、 Systems biology
摘要: Systems Biology is the quantitative analysis of dynamic interactions among several components a biochemical system, aiming at an understanding behavior system as whole. From experimental perspective, systems biology suitable tool to support biologist in process hypotheses generation and efficient design experiments. In this chapter, we discuss elements methodology based on interaction between biologists theoreticians. We, furthermore, show use such case study, analyzing receptor transcription factor modulation affecting responsiveness JAK2/STAT5 pathway.
sci-hub.se 参考文章(38)
Ravi Iyengar, Editorial [2007 IET Systems Biology] Iet Systems Biology. ,vol. 1, pp. 1- 1 ,(2007)
Ursula Klingmuller, The role of tyrosine phosphorylation in proliferation and maturation of erythroid progenitor cells--signals emanating from the erythropoietin receptor. FEBS Journal. ,vol. 249, pp. 637- 647 ,(1997) , 10.1111/J.1432-1033.1997.T01-1-00637.X
J.Dedrick Jordan, Emmanuel M Landau, Ravi Iyengar, Signaling Networks: The Origins of Cellular Multitasking Cell. ,vol. 103, pp. 193- 200 ,(2000) , 10.1016/S0092-8674(00)00112-4
A. Hoffmann, The Ikappa B-NF-kappa B Signaling Module: Temporal Control and Selective Gene Activation Science. ,vol. 298, pp. 1241- 1245 ,(2002) , 10.1126/SCIENCE.1071914
Svetoslav Nikolov, Julio Vera, Vladimir Kotev, Olaf Wolkenhauer, Valko Petrov, Dynamic properties of a delayed protein cross talk model. BioSystems. ,vol. 91, pp. 51- 68 ,(2008) , 10.1016/J.BIOSYSTEMS.2007.07.004
Andrea Ciliberto, Bela Novak, John J. Tyson, Steady States and Oscillations in the p53/Mdm2 Network Cell Cycle. ,vol. 4, pp. 488- 493 ,(2005) , 10.4161/CC.4.3.1548
Hiroaki Kitano, Towards a theory of biological robustness. Molecular Systems Biology. ,vol. 3, pp. 137- 137 ,(2007) , 10.1038/MSB4100179
Hiroaki Kitano, Cancer robustness: Tumour tactics Nature. ,vol. 426, pp. 125- 125 ,(2003) , 10.1038/426125A
Reinhart Heinrich, Benjamin G. Neel, Tom A. Rapoport, Mathematical Models of Protein Kinase Signal Transduction Molecular Cell. ,vol. 9, pp. 957- 970 ,(2002) , 10.1016/S1097-2765(02)00528-2
O. Wolkenhauer, Essay: Defining Systems Biology: An Engineering Perspective Iet Systems Biology. ,vol. 1, pp. 204- 206 ,(2007) , 10.1049/IET-SYB:20079017