A Metaanalysis of Controlled Trials of Neuroleptic Treatment in Dementia

摘要: Prior qualitative literature reviews about the use of neuroleptics in dementia suggest that they are “modestly effective” treating agitation and no single neuroleptic is better than another. To develop a more precise concept clinical efficacy neuroleptics, meta-analytic review existing was performed. From double-blind trials compared with placebo agitated patients, P values effect-size estimates were obtained, assessed by metaanalytic techniques. Results indicated significantly effective (one-tailed = .004) had small effect size (r .18). Clinically, treatment changed improvement rate patients from .41 to .59 (binomial display). This indicates 18 100 benefited (beyond placebo) consistent modest described previous reviews. In six studies comparing thioridazine another neuroleptic, five haloperidol metaanalysis results did not show these two medications differed comparison medications, which inconsistent opinion