Genomic and transcriptomic features of response to anti-pd-1 therapy in metastatic melanoma

作者: Willy Hugo , Jesse M. Zaretsky , Lu Sun , Chunying Song , Blanca Homet Moreno

DOI: 10.1016/J.CELL.2016.02.065

关键词: Immune checkpointNivolumabMAPK/ERK pathwayCancer researchMelanomaDNA repairCancerBiologyBRCA2 ProteinAngiogenesis

摘要: … or resistance to anti-PD-1 therapy. We find that … anti-PD-1 resistance), indicating concurrent up-expression of genes involved in the regulation of mesenchymal transition, cell adhesion, …

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