Inactivation of visna virus and other enveloped viruses by free fatty acids and monoglycerides.
作者： HALLDOR THORMAR , CHARLES E. ISAACS , KWANG KIM , HANNAH R. BROWN
DOI: 10.1111/J.1749-6632.1994.TB38948.X
关键词: Visna-maedi virus 、 Lipolysis 、 Glyceride 、 Biology 、 Titer 、 Microbiology 、 Herpes simplex virus 、 Visna virus 、 Vesicular stomatitis virus 、 Viral envelope 、 Biochemistry
摘要: Human milk was found to become antiviral during storage at 4 degrees C because of the release fatty acids by lipolysis. The stored caused more than a 10,000-fold inactivation visna virus incubation 37 for 30 minutes. Medium-chain saturated and long-chain unsaturated inactivated other enveloped viruses causing 3000-fold reduction in titer. 1-Monoglycerides ethers medium-chain were corresponding free acids. Antiviral affect viral envelope, leakage and, higher concentrations, complete disintegration envelope particles. Lipids commonly natural products could possibly be used as agents against viruses.
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sci-hub.se 参考文章(16)
A. Howard Fieldsteel, Nonspecific antiviral substances in human milk active against arbovirus and murine leukemia virus. Cancer Research. ,vol. 34, pp. 712- 715 ,(1974)
Dan H. Moore, Jesse Charney, Nurul H. Sarkar, Arnold S. Dion, Effect of Human Milk on the Mouse Mammary Tumor Virus Cancer Research. ,vol. 33, pp. 626- 629 ,(1973)
Albert B. Sabin, RELATIONSHIPS BETWEEN ARTHROPOD-BORNE VIRUSES BASED ON ANTIGENIC ANALYSIS, GROWTH REQUIREMENTS, AND SELECTIVE BIOCHEMICAL INACTIVATION Annals of the New York Academy of Sciences. ,vol. 56, pp. 580- 582 ,(1953) , 10.1111/J.1749-6632.1953.TB30250.X
J.K. Welsh, J.T. May, Anti-infective properties of breast milk. The Journal of Pediatrics. ,vol. 94, pp. 1- 9 ,(1979) , 10.1016/S0022-3476(79)80340-6
H Thormar, C E Isaacs, H R Brown, M R Barshatzky, T Pessolano, Inactivation of enveloped viruses and killing of cells by fatty acids and monoglycerides. Antimicrobial Agents and Chemotherapy. ,vol. 31, pp. 27- 31 ,(1987) , 10.1128/AAC.31.1.27
J. A. Levy, J. N. Ihle, O. Oleszko, R. D. Barnes, Virus-specific neutralization by a soluble non-immunoglobulin factor found naturally in normal mouse sera. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 72, pp. 5071- 5075 ,(1975) , 10.1073/PNAS.72.12.5071
Halldór Thormar, Herdis Magnus, Neutralization of visna virus by human sera. Apmis. ,vol. 57, pp. 261- 267 ,(2009) , 10.1111/J.1699-0463.1963.TB05093.X
Morton Klein, The significance of human antiviral neutralizing substances in animal sera. Annals of the New York Academy of Sciences. ,vol. 70, pp. 362- 368 ,(1958) , 10.1111/J.1749-6632.1958.TB35394.X
Jon J. Kabara, Lipids as Host-Resistance Factors of Human Milk Nutrition Reviews. ,vol. 38, pp. 65- 73 ,(2009) , 10.1111/J.1753-4887.1980.TB05843.X
H. THORMAR, H. M. WISNIEWSKI, F. H. LIN, Sera and cerebrospinal fluids from normal uninfected sheep contain a visna virus inhibiting factor. Nature. ,vol. 279, pp. 245- 246 ,(1979) , 10.1038/279245A0