Virus-specific neutralization by a soluble non-immunoglobulin factor found naturally in normal mouse sera.

摘要: A low-molecular-weight substance found naturally in mouse serum neutralizes xenotropic C-type virus. It has no effect on endogenous ecotropic viruses. This neutralizing factor does not belong to the known immunogloblin classes, and its activity is associated with antivirus immunoglobulins that can be detected by radioimmunoprecipitation. Preparations of virus absorb out this sera. The specificity for X-tropic suggests it represents a newly recognized type response host an Its possible role regulation viruses considered.