Structure-Activity Relationships and Drug Disposition

摘要: Drug disposition is of prime concern to pharmacologists, toxicologists, and clinicians. In many cases the variation in absorption, distribution, metabolism, excretion a series congeners governed by molecular structure physicochemical properties drug molecule. When reproducible results sufficient spread are available, these data can be analyzed quantitative terms. order achieve high degree selective toxicity designing better safer therapeutic agents, multifacet effects modification on must thoroughly investigated. It hoped that more systematic effort will directed toward correlation various pharmacokinetic parameters toxicological drugs with their structures.