B) Mechanisms of peptide and protein absorption

摘要: Abstract The significance of the paracellular pathway in both absorption and secretion therapeutic compounds by intestine has received little attention to date. A growing body literature firmly documents importance this aqueous as a major contributor transepithelial flow water solutes wide spectrum epithelia, including small large intestine. relative contributions cellular pathways intestinal are discussed with respect diffusion convective water. Emphasis is placed on interaction net absorption. discussion extended intriguing observations that permeability tight junction may be under active regulation glucose amino acids through cytoskeletal connections perijunctional actomyosin complex. review cites studies from other suggesting universal character transport between, well through, cells attempts establish physiological criteria for assessing contribution compounds, peptides peptidomimetics.