COSTIMULATION BLOCKADE IN PIG ARTERY PATCH XENOTRANSPLANTATION – A SIMPLE MODEL TO MONITOR THE ADAPTIVE IMMUNE RESPONSE IN NONHUMAN PRIMATES
作者： Mohamed B. Ezzelarab , Burcin Ekser , Gabriel Echeverri , Hidetaka Hara , Corin Ezzelarab
DOI: 10.1111/J.1399-3089.2012.00711.X
关键词: Blockade 、 CD40 、 CD28 、 Acquired immune system 、 Xenotransplantation 、 Immunology 、 Biology 、 Transplantation 、 Immunosuppression 、 Immune system
摘要: Background CD154-blockade-based immunosuppression successfully prevents both humoral and cellular adaptive immune responses in baboons receiving α1,3-galactosyltransferase gene-knockout (GTKO) pig organs. Using a GTKO artery transplantation model baboons, we evaluated the efficacy of CD28/B7 costimulatory pathway blockade comparison to CD154-blockade.
elsevier.com
utsystem.edu参考文章(27)
Tatsuo Kawai, David Andrews, Robert B. Colvin, David H. Sachs, A. Benedict Cosimi, Thromboembolic complications after treatment with monoclonal antibody against CD40 ligand. Nature Medicine. ,vol. 6, pp. 114- 114 ,(2000) , 10.1038/72162
P. Thompson, K. Cardona, M. Russell, I. R. Badell, V. Shaffer, G. Korbutt, G. R. Rayat, J. Cano, M. Song, W. Jiang, E. Strobert, R. Rajotte, T. Pearson, A. D. Kirk, C. P. Larsen, CD40‐Specific Costimulation Blockade Enhances Neonatal Porcine Islet Survival in Nonhuman Primates American Journal of Transplantation. ,vol. 11, pp. 947- 957 ,(2011) , 10.1111/J.1600-6143.2011.03509.X
Richard S. Lee, Kazuhiko Yamada, Karl L. Womer, Edmund P. Pillsbury, Kenneth S. Allison, Ariane E. Marolewski, Dong Geng, Aron D. Thall, J. Scott Arn, David H. Sachs, Mohamed H. Sayegh, Joren C. Madsen, Blockade of CD28-B7, But Not CD40-CD154, Prevents Costimulation of Allogeneic Porcine and Xenogeneic Human Anti-Porcine T Cell Responses The Journal of Immunology. ,vol. 164, pp. 3434- 3444 ,(2000) , 10.4049/JIMMUNOL.164.6.3434
Gang Chen, Hua Qian, Thomas Starzl, Hongtao Sun, Bertha Garcia, Ximo Wang, Yishai Wise, Yuanqing Liu, Ying Xiang, Laura Copeman, Weihua Liu, Anthony Jevnikar, William Wall, David K C Cooper, Noriko Murase, Yifan Dai, Wanyu Wang, Yuliang Xiong, David J White, Robert Zhong, Acute rejection is associated with antibodies to non-Gal antigens in baboons using Gal-knockout pig kidneys Nature Medicine. ,vol. 11, pp. 1295- 1298 ,(2005) , 10.1038/NM1330
Mohamed Ezzelarab, Bertha Garcia, Agnes Azimzadeh, Hongtao Sun, Chih Che Lin, Hidetaka Hara, Sean Kelishadi, Tianshu Zhang, Yih Jyh Lin, Hao-Chi Tai, Robert Wagner, Jnanesh Thacker, Noriko Murase, Kenneth McCurry, Rolf N. Barth, David Ayares, Richard N. Pierson, David K.C. Cooper, The Innate Immune Response and Activation of Coagulation in α1,3-Galactosyltransferase Gene-Knockout Xenograft Recipients Transplantation. ,vol. 87, pp. 805- 812 ,(2009) , 10.1097/TP.0B013E318199C34F
M. E. White-Scharf, D. H. Sachs, S. C. Robson, M. Awwad, D. K. C. Cooper, L. Buhler, K. Yamada, H. Kitamura, I. P. J. Alwayn, M. Basker, J. Z. Appel, R. B. Colvin, Pig kidney transplantation in baboons: anti-Gal(alpha)1-3Gal IgM alone is associated with acute humoral xenograft rejection and disseminated intravascular coagulation. Transplantation. ,vol. 72, pp. 1743- 1752 ,(2001) , 10.1097/00007890-200112150-00007
Christoph Knosalla, Bernd Gollackner, David K. C. Cooper, Anti-CD154 monoclonal antibody and thromboembolism revisited Transplantation. ,vol. 74, pp. 416- 417 ,(2002) , 10.1097/00007890-200208150-00024
M. Basker, S. Gojo, A. Watts, S. Treter, K. Nash, G. Oravec, Q. Chang, A. Thall, J. D. Down, M. Sykes, D. Andrews, R. Sackstein, M. E. White-Scharf, D. H. Sachs, D. K. C. Cooper, High-dose porcine hematopoietic cell transplantation combined with CD40 ligand blockade in baboons prevents an induced anti-pig humoral response. Transplantation. ,vol. 69, pp. 2296- 2304 ,(2000) , 10.1097/00007890-200006150-00013
V. L. Willman, C. R. Hanlon, Heart transplantation in primates. Annals of the New York Academy of Sciences. ,vol. 162, pp. 156- 160 ,(1969) , 10.1111/J.1749-6632.1969.TB56358.X
Christoph Knosalla, Bernd Gollackner, Leo Bühler, Nicolas J. Mueller, Stuart Houser, Shamila Mauiyyedi, David H. Sachs, Simon C. Robson, Jay Fishman, Henk-Jan Schuurman, Michel Awwad, David K. C. Cooper, Correlation of biochemical and hematological changes with graft failure following pig heart and kidney transplantation in baboons. American Journal of Transplantation. ,vol. 3, pp. 1510- 1519 ,(2003) , 10.1046/J.1600-6135.2003.00258.X