作者: Wei Qingqing , Cheng Xiaoyang , Chen Keying , Hu Jun , Li Minqian
DOI: 10.1360/02YC9025
关键词: SKELETAL MUSCLE RYANODINE RECEPTOR 、 Chemistry 、 Ryanodine receptor 、 RYR1 、 Atomic force microscopy 、 Elasticity (economics) 、 Biophysics 、 Calcium release channel 、 Phospholipid 、 Anatomy 、 Skeletal muscle 、 General Biochemistry, Genetics and Molecular Biology 、 General Agricultural and Biological Sciences 、 General Environmental Science
摘要: Atomic force microscope was applied to investigate the effect of extrinsic phospholipid on structure rabbit skeletal muscle ryanodine receptor/calcium release channel (RyR1). In addition, in presence phospholipid, height and elasticity RyR1s different functional states were also measured. The results indicate: (i) most showed a normal only phospholipid; (ii) treatment with AMP Ca2+ together could increase their Young’s Modulus but not change apparent height; (iii) no detectable either or appeared, if treated other activators inhibitors.