The heterogeneous nuclear ribonucleoprotein K (hnRNP K) interacts with dengue virus core protein.

摘要: Heterogeneous nuclear ribonucleoprotein K (hnRNP K), a component of hnRNP particles, is involved in several steps gene expression regulation. Dengue (DEN) virus, member the Flaviviridae, primary cause illnesses such as dengue fever, hemorrhagic and shock syndrome. In mature DEN virus core protein structural that forms nucleocapsid complex with genomic RNA. Very little its biologic functions known. Here, using an vitro binding assay coimmunoprecipitation analysis, we report protein-protein interaction between K. The C-terminal hydrophilic region protein, spanning amino acid residues 73 to 100, required for interaction. Results glutathione-S transferase assays indicated protein-hnRNP might be abolished presence cognate nucleic acids. Furthermore, cotransfection experiment, repressive effect ...