Pathogenesis and pathophysiology of yellow fever.

摘要: It will be apparent to the reader that there is much learn about pathogenesis of YF. The role specific genes and molecular determinants neurotropism viscerotropism has been defined only partially. availability infectious clones a small animal (hamster) model should allow dissection virulence factors, which can then tested in more difficult monkey model. marked differences between wild-type YF strains evaluated by evaluating relationships genome sequence. cytokine dysregulation endothelial injury elucidated as access patients sophisticated medical care improves. number cases unvaccinated travelers hospitalized after return from tropics unfortunately increased, but such afford unique opportunities study renal failure, coagulopathy, vascular instability, shock, well new treatment modalities. At cellular level, are also important for research on virus-cell receptor interactions, control apoptotic cell death, predilection cells midzone liver lobule. dendritic early stage infection deserving study. Finally, immune response infection, particularly immunity, poorly characterized, suggestion clearance may aggravate condition host during period intoxication appropriate models.