Endotoxin and the liver: III. Modification of acute carbon tetrachloride injury by polymyxin B—an antiendotoxin

摘要: Abstract Previous work suggests that endotoxin of enteric origin may contribute to both acute and chronic liver injury by other agents. In particular, evidence exists tolerance modifies biochemical histological carbon tetrachloride hepatotoxicity. The present study was undertaken ascertain whether another method modifying endotoxicity would protect against (CCl 4 ) damage as well. antibiotic polymyxin B (PB) has unique antiendotoxin properties not shared gentamicin sulfate, an with a similar antibacterial spectrum. groups rats pretreated either PB, gentamicin, or diluent, the ld 100 oral dose CCl reduced PB 50 , but pretreatment without effect. When sublethal administered, SGOT SGPT values were significantly lower in group rats. This protection mirrored striking lack necrosis these animals, controls. incidence endotoxemia 24 hr after detected lead acetate enhancement also pretreatment. These findings further support contention endotoxins from gut be major contributors extent induced unrelated toxin.