ABERRANT INTEGRIN EXPRESSION IN THE ENDOMETRIUM OF WOMEN WITH ENDOMETRIOSIS

作者: B A Lessey , A J Castelbaum , S W Sawin , C A Buck , R Schinnar

DOI: 10.1210/JCEM.79.2.7519194

关键词: EndometriosisBiologyEndometriosis and infertilityMenstrual cycleInternal medicineVitronectinEndometriumEndocrinologyIntegrinAlpha-v beta-3Endometrial biopsy

摘要: Integrins are ubiquitous cell adhesion molecules that undergo dynamic alterations during the normal menstrual cycle in human endometrium. The alpha v beta 3 vitronectin receptor integrin is expressed endometrium at time of implantation, but its presence delayed assessed to be out phase using classical histological features. To investigate expression this women with endometriosis, we 3-subunit throughout 268 "in-phase" endometrial biopsies, immunohistochemistry. was on epithelium after days 19-20 cycle. In 241 whose biopsies were obtained day 19, a lack found closely related diagnosis endometriosis (by Wilcoxon test, P = 0.02). This defect associated nulliparity, inversely stage disease, and occurred despite in-p...

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