Chagas' disease and Duffy antigen/receptor for chemokine (DARC): a mini-review
作者： AP Oliveira , LC Mattos , CE Cavasini
DOI: 10.1590/S1678-91992011000300005
关键词: Receptor 、 Chemokine 、 Chagas disease 、 Antigen 、 Homeostasis 、 Immunology 、 Disease 、 Gene 、 Biology 、 Glycoprotein
摘要: Duffy gene (FY) codifies the transmembrane glycoprotein (gp-Fy) of 35 to 43 kDa which is moderately immunogenic. This polymorphic, and constitutes antigens histo-blood system were designated receptors for chemokines denominated DARC (Duffy antigen/receptor chemokine). receptor has an important role in regulation chemokine levels circulation, as it binds adsorbs them on surface red cells a reservoir. It plays "sink" role, can contribute homeostasis by removing inflammatory from circulation well maintaining plasmatic levels. Chronic Chagas' cardiopathy (CCC) most frequent form disease. disease, infiltrated play development progress infection. High plasma have been associated with disease severity patients heart failure. In this context, profile expression could function CCC, modulate damage
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