The neuroprotective effect of a nitric oxide inhibitor in a rat model of focal cerebral ischaemia.
作者： A. Buisson , M. Plotkine , R.G. Boulu
DOI: 10.1111/J.1476-5381.1992.TB14410.X
关键词: Middle cerebral artery 、 Nitric oxide synthase 、 Nitric oxide 、 Pharmacology 、 Neuroprotection 、 Biochemistry 、 Brain ischemia 、 Necrosis 、 Ischemia 、 Biology 、 Glutamate receptor
摘要: Recent data showed that glutamate toxicity in primary cortical cultures is mediated by nitric oxide. In order to investigate the effect of inhibition NO synthase on focal cerebral ischaemia rats, we studied histological consequences a middle artery (MCA) occlusion after post-operative treatment with NG-nitro-L-arginine methyl ester, an inhibitor oxide synthase. We found significant reduction (-43%) and striatal (-25%) necrotic volumes induced MCA occlusion, indicating synthesis plays important role neurotoxic cascade leading neuronal damage rats.
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