Hypothalamic-Pituitary-Gonadal Activity in Paradoxical and Psychophysiological Insomnia.

摘要: Objective: Although insomnia is a sex-dimorphic disorder, there limited knowledge about the association between sex hormones and insomnia. In present study, we aimed to investigate level of hypothalamus-pituitary-gonadal (HPG) axis activity in patients with by measuring serum levels luteinizing hormone (LH), follicle stimulating (FSH), 17a-Hydroxyprogesterone, testosterone, progesterone, estradiol, dehydroepiandrosterone sulfate, hormone-binding globulin. Materials Methods: Numbers 19 patients; including 13 females (68.4%) paradox (32-53 years; 43.2 ± 6.4) 17 8 (47.1%) psychophysiological (14-62 38.4 ± 16.3) were recruited. Seventeen aged-matched normal sleeper consisted males (26-59 40.7 ± 10) also recruited as control group. Insomnia was diagnosed sleep clinician according International Classification Sleep Disorders-Second Edition criteria an overnight polysomnography (PSG). A volume 5 ml venous blood samples collected, prepared, stored at AM under standard condition. Serum measured using enzyme-linked immunosorbent assay kits. Data analyzed Chi-square ANCOVA. Multiple linear regression analysis used evaluate associations PSG biochemical parameters. Results: There no significant differences all analyses two subgroups (paradoxical insomnia) sleepers. Testosterone positively related maximum pulse transit time (PTT). Moreover, both LH FSH associated wake index diastolic pressure. Conclusion: HPG's groups, testosterone PTT.