Changes in lung function among treated HIV-positive and HIV-negative individuals: analysis of the prospective AGEhIV cohort study
作者： Neeltje Kootstra , Reindert P van Steenwijk , Marc van der Valk , M Bradley Drummond , Gregory D Kirk
DOI: 10.1016/S2666-7568(21)00033-7
关键词: FEV1/FVC ratio 、 Human immunodeficiency virus (HIV) 、 Spirometry 、 Vital capacity 、 Internal medicine 、 Medicine 、 Prospective cohort study 、 Cohort study 、 Lung function 、 Cohort
摘要: Summary Background The AGEhIV cohort study is a prospective evaluating the occurrence of age-related comorbidities in people living with and without HIV. We previously reported lower forced vital capacity (FVC) HIV-positive compared HIV-negative participants those heavy smoking exposure at time enrolment study. In this we evaluate longitudinal changes spirometry indices same accounting for behaviour other risk factors. Methods obtained pre-bronchodilator measurements during biennial visits over median 5·9 years (IQR 5·7–6·0). Adjusted declines expiratory volume 1 s (FEV1), FVC, FEV1/FVC ratio were modelled using linear mixed-effects models by HIV status status. To whether could be driven increased levels chronic inflammation, assessed associations between rates FEV1 FVC decline CD4 CD8 T-cell counts, plasma concentrations C-reactive protein (CRP), interleukin 6, soluble CD14, CD163, intestinal fatty-acid-binding separate models. registered ClinicalTrials.gov , NCT01466582 . Findings 500 481 included data from Oct 29, 2010, to Aug 14, 2018. virally suppressed ( Interpretation Treated infection was associated faster both but not ratio. These independent might have been ongoing interstitial or small airway damage, potentially related inflammation. Funding ZonMW, Aidsfonds, Gilead Sciences, ViiV Healthcare, Janssen Pharmaceuticals, Merck.
sci-hub.st 参考文章(27)
Kristina Crothers, Adeel A Butt, Cynthia L Gibert, Maria C Rodriguez-Barradas, Stephen Crystal, Amy C Justice, Veterans Aging Cohort 5 Project Team, Increased COPD among HIV-positive compared to HIV-negative veterans. Chest. ,vol. 130, pp. 1326- 1333 ,(2006) , 10.1378/CHEST.130.5.1326
Michael Bradley Drummond, Christian A. Merlo, Jacquie Astemborski, Mariah M. Kalmin, Annamarie Kisalu, John F. Mcdyer, Shruti H. Mehta, Robert H. Brown, Robert A. Wise, Gregory D. Kirk, The effect of HIV infection on longitudinal lung function decline among IDUs: a prospective cohort. AIDS. ,vol. 27, pp. 1303- 1311 ,(2013) , 10.1097/QAD.0B013E32835E395D
Kristina Crothers, Kathleen McGinnis, Eric Kleerup, Cherry Wongtrakool, Guy S. Hoo, Joon Kim, Amir Sharafkhaneh, Laurence Huang, Zhaoyu Luo, Bruce Thompson, Philip Diaz, Gregory D. Kirk, William Rom, Roger Detels, Lawrence Kingsley, Alison Morris, HIV infection is associated with reduced pulmonary diffusing capacity Journal of Acquired Immune Deficiency Syndromes. ,vol. 64, pp. 271- 278 ,(2013) , 10.1097/QAI.0B013E3182A9215A
Philip H. Quanjer, Sanja Stanojevic, Tim J. Cole, Xaver Baur, Graham L. Hall, Bruce H. Culver, Paul L. Enright, John L. Hankinson, Mary S.M. Ip, Jinping Zheng, Janet Stocks, , Multi-ethnic reference values for spirometry for the 3–95-yr age range: the global lung function 2012 equations European Respiratory Journal. ,vol. 40, pp. 1324- 1343 ,(2012) , 10.1183/09031936.00080312
J. Schouten, F. W. Wit, I. G. Stolte, N. A. Kootstra, M. van der Valk, S. E. Geerlings, M. Prins, P. Reiss, P. Reiss, F. W. N. M. Wit, M. van der Valk, J. Schouten, K. W. Kooij, R. A. van Zoest, B. C. Elsenga, M. Prins, I. G. Stolte, M. Martens, S. Moll, J. Berkel, L. Moller, G. R. Visser, C. Welling, S. Zaheri, M. M. J. Hillebregt, L. A. J. Gras, Y. M. C. Ruijs, D. P. Benschop, P. Reiss, N. A. Kootstra, A. M. Harskamp-Holwerda, I. Maurer, M. M. Mangas Ruiz, A. F. Girigorie, E. van Leeuwen, F. R. Janssen, M. Heidenrijk, J. H. N. Schrijver, W. Zikkenheiner, M. Wezel, C. S. M. Jansen-Kok, S. E. Geerlings, M. H. Godfried, A. Goorhuis, J. T. M. van der Meer, F. J. B. Nellen, T. van der Poll, J. M. Prins, P. Reiss, M. van der Valk, W. J. Wiersinga, F. W. N. M. Wit, J. van Eden, A. Henderiks, A. M. H. van Hes, M. Mutschelknauss, H. E. Nobel, F. J. J. Pijnappel, A. M. Westerman, J. de Jong, P. G. Postema, P. H. L. T. Bisschop, M. J. M. Serlie, P. Lips, E. Dekker, S. E. J. A. de Rooij, J. M. R. Willemsen, L. Vogt, J. Schouten, P. Portegies, B. A. Schmand, G. J. Geurtsen, J. A. ter Stege, M. Klein Twennaar, B. L. F. van Eck-Smit, M. de Jong, D. J. Richel, F. D. Verbraak, N. Demirkaya, I. Visser, H. G. Ruhe, P. T. Nieuwkerk, R. P. van Steenwijk, E. Dijkers, C. B. L. M. Majoie, M. W. A. Caan, T. Su, H. W. van Lunsen, M. A. F. Nievaard, B. J. H. van den Born, E. S. G. Stroes, W. M. C. Mulder, , Cross-sectional comparison of the prevalence of age-associated comorbidities and their risk factors between HIV-infected and uninfected individuals: the AGEhIV Cohort Study Clinical Infectious Diseases. ,vol. 59, pp. 1787- 1797 ,(2014) , 10.1093/CID/CIU701
Martin R Miller, JATS Hankinson, Vito Brusasco, F Burgos, R Casaburi, A Coates, R Crapo, Pvd Enright, CPM Van Der Grinten, P Gustafsson, R Jensen, DC Johnson, N MacIntyre, R McKay, D Navajas, OF Pedersen, R Pellegrino, G Viegi, JATS Wanger, None, Standardisation of spirometry European Respiratory Journal. ,vol. 26, pp. 319- 338 ,(2005) , 10.1183/09031936.05.00034805
Irálice AV Jansen, Ronald B Geskus, Udi Davidovich, Suzanne Jurriaans, Roel A Coutinho, Maria Prins, Ineke G Stolte, Ongoing HIV-1 transmission among men who have sex with men in Amsterdam: a 25-year prospective cohort study AIDS. ,vol. 25, pp. 493- 501 ,(2011) , 10.1097/QAD.0B013E328342FBE9
Shawn D. Aaron, Robert E. Dales, Pierre Cardinal, How Accurate Is Spirometry at Predicting Restrictive Pulmonary Impairment Chest. ,vol. 115, pp. 869- 873 ,(1999) , 10.1378/CHEST.115.3.869
Engi F. Attia, Kathleen M. Akgün, Cherry Wongtrakool, Matthew Bidwell Goetz, Maria C. Rodriguez-Barradas, David Rimland, Sheldon T. Brown, Guy W. Soo Hoo, Joon Kim, Patty J. Lee, Lynn M. Schnapp, Amir Sharafkhaneh, Amy C. Justice, Kristina Crothers, Increased Risk of Radiographic Emphysema in HIV Is Associated With Elevated Soluble CD14 and Nadir CD4 Chest. ,vol. 146, pp. 1543- 1553 ,(2014) , 10.1378/CHEST.14-0543
Meghan E. Fitzpatrick, Mehdi Nouraie, Matthew R. Gingo, Danielle Camp, Cathy J. Kessinger, James B. Sincebaugh, Andrew Clarke, John W. Ries, Eric C. Kleerup, Lawrence Kingsley, Alison Morris, Novel relationships of markers of monocyte activation and endothelial dysfunction with pulmonary dysfunction in HIV-infected persons. AIDS. ,vol. 30, pp. 1327- 1339 ,(2016) , 10.1097/QAD.0000000000001092