The effect of HIV infection on longitudinal lung function decline among IDUs: a prospective cohort.

摘要: The advancement of anti-retroviral therapy (ART) has led to improved survival and longer life expectancy for persons living with human immunodeficiency virus (HIV) infection.[1-3] Subsequently there is increased recognition development age-associated chronic diseases (e.g., cardiovascular, metabolic, renal, neurological) non-AIDS-defining malignancies occurring in these individuals.[4-8] Emerging data suggests an prevalence lung disease HIV-infected individuals, the spectrum which includes both airflow obstruction restrictive disease.[9-12] HIV-infection been shown increase diagnosis self-reported administratively diagnosed COPD.[13, 14] We have previously that odds were >3-fold among individuals highest plasma viral load independent smoking compared epidemiologically similar HIV-negative individuals.[15] Respiratory infections, are associated disease.[12] Beyond cross-sectional reports, few studies evaluated longitudinal function decline persons.[12, 16] Because earlier prior widespread ART availability recent limited by small numbers persons, short duration follow-up, lack comparator groups, effect HIV markers on remains unanswered. The AIDS Linked Intravenous Experience (ALIVE) study a cohort history injecting drugs or at-risk infection followed Baltimore, Maryland since 1988.[17] ALIVE collects behavioral, clinical, laboratory at regular six-month intervals recently instituted serial spirometric measures into collection protocol. With nearly ubiquitous cigarette substantial respiratory symptoms obstructive (OLD),[18-20] represents appropriate population examine changes function. In current study, we use from determine association over almost three years observations. hypothesized infection, particularly more advanced disease, would be accelerated decline. Some results presented 19th Conference Retroviruses Opportunistic Infections published abstract form.[21]