HIV-associated obstructive lung diseases: insights and implications for the clinician

摘要: Summary The effectiveness of antiretroviral therapy to control HIV infection has led the emergence an older population who are at risk chronic diseases. Through a comprehensive search major databases, this Review summarises information about associations between obstructive pulmonary disease (COPD), asthma, and infection. Asthma COPD more prevalent in HIV-infected populations; 16–20% individuals with have asthma or COPD, poorly controlled worsens spirometric diffusing capacity measurements, accelerates lung function decline by 55–75 mL/year. Up 21% ventilatory defects reduced is seen than 50% populations. Specific pharmacotherapy considerations needed care for populations COPD–protease inhibitor regimens treat (such as ritonavir) can result systemic accumulation inhaled corticosteroids might increase pneumonia risk, exacerbating toxicity therapy. Therefore, it essential clinicians heightened awareness increased manifestations diseases patients specific therapeutic population. Screening spirometry tests be beneficial people history smoking respiratory symptoms.