The Bcl-2 specific BH3 mimetic ABT-199: a promising targeted therapy for t(11;14) multiple myeloma

Cassandra J. Vandenberg, Suzanne Cory, ABT-199, a new Bcl-2–specific BH3 mimetic, has in vivo efficacy against aggressive Myc-driven mouse lymphomas without provoking thrombocytopenia Blood. ,vol. 121, pp. 2285- 2288 ,(2013) , 10.1182/BLOOD-2013-01-475855

H Avet-Loiseau, M Roussel, L Campion, X Leleu, G Marit, H Jardel, M Dib, O Decaux, T Lamy, M Tiab, P Cony-Makhoul, A Banos, G Lepeu, F Lifermann, M Macro, B Kolb, C Hulin, D Caillot, C Traulle, C Mathiot, B Royer, Cytogenetic and therapeutic characterization of primary plasma cell leukemia: the IFM experience. Leukemia. ,vol. 26, pp. 158- 159 ,(2012) , 10.1038/LEU.2011.176

V Labi, F Grespi, F Baumgartner, A Villunger, Targeting the Bcl-2-regulated apoptosis pathway by BH3 mimetics: a breakthrough in anticancer therapy? Cell Death & Differentiation. ,vol. 15, pp. 977- 987 ,(2008) , 10.1038/CDD.2008.37

C Fernández de Larrea, , R A Kyle, B G M Durie, H Ludwig, S Usmani, D H Vesole, R Hajek, J F San Miguel, O Sezer, P Sonneveld, S K Kumar, A Mahindra, R Comenzo, A Palumbo, A Mazumber, K C Anderson, P G Richardson, A Z Badros, J Caers, M Cavo, X LeLeu, M A Dimopoulos, C S Chim, R Schots, A Noeul, D Fantl, U-H Mellqvist, O Landgren, A Chanan-Khan, P Moreau, R Fonseca, G Merlini, J J Lahuerta, J Bladé, R Z Orlowski, J J Shah, Plasma cell leukemia: consensus statement on diagnostic requirements, response criteria and treatment recommendations by the International Myeloma Working Group Leukemia. ,vol. 27, pp. 780- 791 ,(2013) , 10.1038/LEU.2012.336

J. Moreaux, B. Klein, R. Bataille, G. Descamps, S. Maiga, D. Hose, H. Goldschmidt, A. Jauch, T. Reme, M. Jourdan, M. Amiot, C. Pellat-Deceunynck, A high-risk signature for patients with multiple myeloma established from the molecular classification of human myeloma cell lines Haematologica. ,vol. 96, pp. 574- 582 ,(2011) , 10.3324/HAEMATOL.2010.033456

David A Tuveson, Alice T Shaw, Nicholas A Willis, Daniel P Silver, Erica L Jackson, Sandy Chang, Kim L Mercer, Rebecca Grochow, Hanno Hock, Denise Crowley, Sunil R Hingorani, Tal Zaks, Catrina King, Michael A Jacobetz, Lifu Wang, Roderick T Bronson, Stuart H Orkin, Ronald A DePinho, Tyler Jacks, None, Endogenous oncogenic K-rasG12D stimulates proliferation and widespread neoplastic and developmental defects Cancer Cell. ,vol. 5, pp. 375- 387 ,(2004) , 10.1016/S1535-6108(04)00085-6

Linda Bodet, Patricia Gomez-Bougie, Cyrille Touzeau, Christelle Dousset, Géraldine Descamps, Sophie Maïga, Hervé Avet-Loiseau, Régis Bataille, Philippe Moreau, Steven Le Gouill, Catherine Pellat-Deceunynck, Martine Amiot, ABT-737 is highly effective against molecular subgroups of multiple myeloma. Blood. ,vol. 118, pp. 3901- 3910 ,(2011) , 10.1182/BLOOD-2010-11-317438

Marina Konopleva, Rooha Contractor, Twee Tsao, Ismael Samudio, Peter P. Ruvolo, Shinichi Kitada, Xingming Deng, Dayong Zhai, Yue-Xi Shi, Thomas Sneed, Monique Verhaegen, Maria Soengas, Vivian R. Ruvolo, Teresa McQueen, Wendy D. Schober, Julie C. Watt, Tilahun Jiffar, Xiaoyang Ling, Frank C. Marini, David Harris, Martin Dietrich, Zeev Estrov, James McCubrey, W. Stratford May, John C. Reed, Michael Andreeff, Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia Cancer Cell. ,vol. 10, pp. 375- 388 ,(2006) , 10.1016/J.CCR.2006.10.006

Andrew W. Roberts, John F. Seymour, Jennifer R. Brown, William G. Wierda, Thomas J. Kipps, Seong Lin Khaw, Dennis A. Carney, Simon Z. He, David C.S. Huang, Hao Xiong, Yue Cui, Todd A. Busman, Evelyn M. McKeegan, Andrew P. Krivoshik, Sari H. Enschede, Rod Humerickhouse, Substantial Susceptibility of Chronic Lymphocytic Leukemia to BCL2 Inhibition: Results of a Phase I Study of Navitoclax in Patients With Relapsed or Refractory Disease Journal of Clinical Oncology. ,vol. 30, pp. 488- 496 ,(2012) , 10.1200/JCO.2011.34.7898

L. Lode, M. Eveillard, V. Trichet, T. Soussi, S. Wuilleme, S. Richebourg, F. Magrangeas, N. Ifrah, L. Campion, C. Traulle, F. Guilhot, D. Caillot, G. Marit, C. Mathiot, T. Facon, M. Attal, J.-L. Harousseau, P. Moreau, S. Minvielle, H. Avet-Loiseau, Mutations in TP53 are exclusively associated with del(17p) in multiple myeloma. Haematologica. ,vol. 95, pp. 1973- 1976 ,(2010) , 10.3324/HAEMATOL.2010.023697