Mutations in TP53 are exclusively associated with del(17p) in multiple myeloma.
作者： L. Lode , M. Eveillard , V. Trichet , T. Soussi , S. Wuilleme
DOI: 10.3324/HAEMATOL.2010.023697
关键词:
摘要: Deletion of the 17p13 chromosomal region [del(17p)] is associated with a poor outcome in multiple myeloma. Most studies have targeted TP53 gene for deletion analyses, although no study showed that this target. In order to address issue, we sequenced 92 patients myeloma at diagnosis, 54 del(17p) and 38 lacking del(17p). At least one mutation was found 20 patients, all them presenting The analysis location virtually occurred highly conserved domains involved DNA-protein interactions. conclusion, 37% present versus 0% prognostic significance these mutations remains be evaluated.
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