Enflurane, halothane, and aminophylline--uptake and pharmacokinetics.

摘要: This study was designed to evaluate the effects of induction enflurane or halothane anesthesia on distribution and elimination previously administered intravenous aminophylline, effect aminophylline uptake halothane. Fifty-four dogs were studied: 6 received no anesthetic, 24 enflurane, The six animals receiving anesthetic given 10 mg/kg aminophylline. In each two groups animals, served as controls Of other 18 in group, 25 50 intravenously before anesthesia. redistribution (alpha) phase theophylline similar when induced with either slightly more rapid following administration. (beta) presence not significantly different than administered. unaffected by prior administration Differences arrhythmogenicity between after are related alterations pharmacokinetics uptake.