Evidence for the involvement of cytochrome P-450 in tiaramide N-oxide reduction
作者： Masahiko Sugiura , Kazuhide Iwasaki , Hideyo Noguchi , Ryuichi Kato
DOI: 10.1016/0024-3205(74)90118-0
关键词: Cytochrome 、 Biochemistry 、 Oxygen 、 Rat liver microsomes 、 Chemistry 、 Phenobarbital 、 Carbon monoxide 、 Metabolite 、 Absorbance 、 Tiaramide N-oxide
摘要: Abstract Tiaramide N-oxide, a major metabolite of tiaramide, is reduced anaerobically to tiaramide by rat liver microsomes. The reaction requires NADPH and inhibited oxygen carbon monoxide. Both phenobarbital 3-methylcholanthrene treatments induced the reductase activity with increasing cytochrome P-450 content. N-oxide produced pronounced spectral change difference spectrum showed peak absorbance at 442 nm. These findings provide evidence in support an essential role for process reduction.
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