Clinical proteomics: translating benchside promise into bedside reality
作者： Emanuel F. Petricoin , Kathryn C. Zoon , Elise C. Kohn , J. Carl Barrett , Lance A. Liotta
DOI: 10.1038/NRD891
关键词: Disease 、 Bioinformatics 、 MEDLINE 、 Neoplasms diagnosis 、 Protein network 、 Proteomics 、 Cancer 、 Model disease 、 Medicine
摘要: The ultimate goal of proteomics is to characterize the information flow through protein networks. This can be a cause, or consequence, disease processes. Clinical an exciting new subdiscipline that involves application proteomic technologies at bedside, and cancer, in particular, model for studying such applications. Here, we describe are being developed detect cancer earlier, discover next generation targets imaging biomarkers, finally tailor therapy patient.
nature.com
sci-hub.se 参考文章(81)
Teuvo Kohonen, Self-organized formation of topologically correct feature maps Biological Cybernetics. ,vol. 43, pp. 509- 521 ,(1988) , 10.1007/BF00337288
Ben R. Herbert, Jean-Charles Sanchez, Luca Bini, Two-Dimensional Electrophoresis: The State of the Art and Future Directions Springer Berlin Heidelberg. pp. 13- 34 ,(1997) , 10.1007/978-3-662-03493-4_2
Benno Schwikowski, Peter Uetz, Stanley Fields, A NETWORK OF PROTEIN?PROTEIN INTERACTIONS IN YEAST Nature Biotechnology. ,vol. 18, pp. 1257- 1261 ,(2000) , 10.1038/82360
Gerard I. Evan, Karen H. Vousden, Proliferation, cell cycle and apoptosis in cancer Nature. ,vol. 411, pp. 342- 348 ,(2001) , 10.1038/35077213
Robert C. Young, William J. Hoskins, Carlos A. Perez, Principles and Practice of Gynecologic Oncology ,(1992)
Rachel A. Craven, Nick Totty, Patricia Harnden, Peter J. Selby, Rosamonde E. Banks, Laser capture microdissection and two-dimensional polyacrylamide gel electrophoresis: evaluation of tissue preparation and sample limitations. American Journal of Pathology. ,vol. 160, pp. 815- 822 ,(2002) , 10.1016/S0002-9440(10)64904-8
Gavin MacBeath, Proteomics comes to the surface. Nature Biotechnology. ,vol. 19, pp. 828- 829 ,(2001) , 10.1038/NBT0901-828
Mark M. Moasser, Steven D. Averbuch, Neal Rosen, Andrea Basso, The Tyrosine Kinase Inhibitor ZD1839 ("Iressa") Inhibits HER2-driven Signaling and Suppresses the Growth of HER2-overexpressing Tumor Cells Cancer Research. ,vol. 61, pp. 7184- 7188 ,(2001)
Michael P. Washburn, Dirk Wolters, John R. Yates, Large-scale analysis of the yeast proteome by multidimensional protein identification technology. Nature Biotechnology. ,vol. 19, pp. 242- 247 ,(2001) , 10.1038/85686
Markus Stoeckli, Pierre Chaurand, Dennis E. Hallahan, Richard M. Caprioli, Imaging mass spectrometry: a new technology for the analysis of protein expression in mammalian tissues. Nature Medicine. ,vol. 7, pp. 493- 496 ,(2001) , 10.1038/86573