Chapter 5 - Microarray Analysis and Proteomic Approaches to Drug Development

摘要: The recent development of microarray and other genomic technologies has revolutionized research into the molecular mechanisms disease. Gene expression patterns human tumor types have been studied using cDNA protein patterns; in many cases, new subtypes identified based on this classification. use gene arrays is particularly relevant to investigations cancer, where these approaches are beginning direct effects diagnosis, disease management, directed drug therapies. data can be useful for identification genetic factors that involved etiology disease, metabolism, transport, kinetics, adverse medications as well determination variations at targets. In arena discovery, technology incorporated each phase process, from validation potential targets correlation with clinical parameters predicting patient responses. This chapter covers analysis application microanalysis novel therapeutics.