Soluble P-selectin and vascular endothelial growth factor in steady state sickle cell disease: relationship to genotype

摘要: Sickle cell disease (SCD) is characterised by abnormal coagulopathy and angiogenesis although their relationships in two common genotypes, homozygous (HbSS) SCD sickle-haemoglobin C (HbSC), are unexplored. We measured markers of platelet activation (soluble P-selectin [sP-selectin]), fibrinolysis (D-dimer) (vascular endothelial growth factor [VEGF]) 27 HbSS patients, 37 HbSC patients 42 age race matched subjects with normal haemoglobin (AA). sP-selectin (P = 0.025) D-dimers < 0.001) were higher than but there was no difference VEGF. In HbSC, sPselectin correlated VEGF 0.012) 0.021). There significant correlations health or HbSS. Platelet coagulation activation, not angiogenic activity, elevated compared to the clinically milder genotype. The correlation between consistent view that released from platelets during vivo activation.