From pharmacogenetics to pharmacogenomics: the way toward the personalization of antidepressant treatment.

摘要: Objective:Major depressive disorder is the most common psychiatric disorder, worldwide, yet response and remission rates are still unsatisfactory. The identification of genetic predictors antidepressant (AD) could provide a promising opportunity to improve current AD efficacy through personalization treatment. major steps findings along this path reviewed together with their clinical implications limitations.Method:We systematically literature MEDLINE Embase database searches, using any word combination “antidepressant,” “gene,” “polymorphism,” “pharmacogenetics,” “genome-wide association study,” “GWAS,” “response,” “adverse drug reactions.” Experimental works reviews published until March 2012 were collected compared.Results:Numerous genes pertaining several functional systems associated response. more robust found for following genes: solute carrier family 6 (neurotransmitter transporter), me...