Suggestibility as a predictor of response to antidepressants: A preliminary prospective trial

摘要: Abstract Background The growing awareness that so many do not respond adequately to antidepressant (AD) pharmacotherapy has sparked research seeking characterize those who do. While the pharmacological mechanisms of AD treatment have been extensively evaluated, much remains unknown about placebo component response medication. This study examined association between suggestibility levels and ADs amongst depressed patients. Methods Twenty unipolar depression outpatients, recruited before starting monotherapy, received clear, standardized instructions therapeutic effects AD, though side effects, would require 2–4 weeks. At baseline (T1), 1 week (T2), month (T3), participants were evaluated for depressive symptoms, using Hamilton Rating Scale Depression-17 items (HAM-D); anxiety by Anxiety (HAM-A); Antidepressant Side Effect Checklist (ASEC); suggestibility, Multidimensional Iowa Suggestibility (MISS). Results High associated with less improvement in level more side-effects during first week. In accordance our hypothesis suggestible patients improved T2 T3. No significant correlations found change anxiety. Limitations Small sample size a self-report questionnaire assessing limitations. Conclusion offers potentially new clinically useful approach understanding predicting will treatment. seems play role, presumably shaping expectation, We hope this avenue be further explored.