Microsatellite polymorphism in the fibrillin 3 gene and susceptibility to PCOS: a case–control study and meta-analysis

摘要: Abstract The D19S884 marker at the fibrillin 3 gene has been analysed as a candidate location for polycystic ovary syndrome (PCOS) mainly in Caucasian descendants. A case–control study was performed with 272 PCOS women and 271 controls to test hypothesis that variants increase susceptibility Chinese meta-analysis undertaken clarify whether there is an allele consistently contributing susceptibility. association analysis showed were significantly different from distribution of frequencies. Instead well-known A8 allele, most common population proved be A7, frequencies A7 statistically between cases ( P =0.037). only identified significant allelic all combined samples (A8: OR 1.391, 95% CI 1.169–1.654; A7: 1.154, 0.894–1.490). In conclusion, potential Han may PCOS. Polycystic endocrine disorder reproductive age, it affects estimated 15% worldwide based on Rotterdam criteria. Many studies descendants suggested are associated risk this syndrome. Here we investigate women. We also carried out some relevant find more reliable result. Our frequencies, instead (the letter ‘A' represents ‘allele'), whose controls. samples. our