Basic research in PCOS: are we reaching new frontiers?

摘要: Polycystic ovarian syndrome (PCOS) is the leading cause for anovulatory infertility. It diagnosed by two of following three clinical criteria: oligomenorrhoea, hyperandrogenism and polycystic appearance ovaries. Weight loss physical activity can lead to ovulation conception. Lowering serum insulin normalizes androgen concentrations whereas induction often causes hyperstimulation. Theca cells from PCOS ovaries may be more responsive than non-PCOS Herein we review research efforts at genomic cell function levels, as well animal models, which have been made elucidate underlying mechanism that leads PCOS. appears that, despite impressive amount data generated in these studies, this still only partially understood. infertility, caused anovulation. irregular prolonged menstrual cycles, overt symptoms excess androgens, revealed acne hair, ultrasonographic with multiple small follicles spread mainly near surface, gave it its name. Intentional weight resumption not infrequently conception well. was shown lowering accounts normalization FSH suggested theca In article define genes responsible studies level, done Overall,