Electron Transport Chain Remodeling by GSK3 during Oogenesis Connects Nutrient State to Reproduction
作者： Matthew H. Sieber , Michael B. Thomsen , Allan C. Spradling
DOI: 10.1016/J.CELL.2015.12.020
关键词:
摘要: Reproduction is heavily influenced by nutrition and metabolic state. Many common reproductive disorders in humans are associated with diabetes syndrome. We characterized the mechanisms that support oogenesis found mitochondria mature Drosophila oocytes enter a low-activity state of respiratory quiescence remodeling electron transport chain (ETC). This shift mitochondrial function leads to extensive glycogen accumulation late required for developmental competence oocyte. Decreased insulin signaling initiates ETC through synthase kinase 3 (GSK3). Intriguingly, we observed similar uptake maturing Xenopus oocytes, suggesting these processes evolutionarily conserved aspects oocyte development. Our studies reveal an important link between metabolism maturation.
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sci-hub.se 参考文章(72)
Karen C Arden, FoxO: linking new signaling pathways. Molecular Cell. ,vol. 14, pp. 416- 418 ,(2004) , 10.1016/S1097-2765(04)00213-8
Rémi Dumollard, Michael Duchen, John Carroll, The role of mitochondrial function in the oocyte and embryo. Current Topics in Developmental Biology. ,vol. 77, pp. 21- 49 ,(2007) , 10.1016/S0070-2153(06)77002-8
Scott Ogg, Suzanne Paradis, Shoshanna Gottlieb, Garth I. Patterson, Linda Lee, Heidi A. Tissenbaum, Gary Ruvkun, The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans Nature. ,vol. 389, pp. 994- 999 ,(1997) , 10.1038/40194
G C Brown, Control of respiration and ATP synthesis in mammalian mitochondria and cells Biochemical Journal. ,vol. 284, pp. 1- 13 ,(1992) , 10.1042/BJ2840001
C. S. Stump, K. R. Short, M. L. Bigelow, J. M. Schimke, K. S. Nair, Effect of insulin on human skeletal muscle mitochondrial ATP production, protein synthesis, and mRNA transcripts Proceedings of the National Academy of Sciences of the United States of America. ,vol. 100, pp. 7996- 8001 ,(2003) , 10.1073/PNAS.1332551100
Jean-Jacques Mermod, Marcelo Jacobs-Lorena, Marco Crippa, Changes in rate of RNA synthesis and ribosomal gene number during oogenesis of Drosophila melanogaster Developmental Biology. ,vol. 57, pp. 393- 402 ,(1977) , 10.1016/0012-1606(77)90224-X
Matthew H. Sieber, Carl S. Thummel, The DHR96 Nuclear Receptor Controls Triacylglycerol Homeostasis in Drosophila Cell Metabolism. ,vol. 10, pp. 481- 490 ,(2009) , 10.1016/J.CMET.2009.10.010
M. E. Pepling, J. E. Wilhelm, A. L. O'Hara, G. W. Gephardt, A. C. Spradling, Mouse oocytes within germ cell cysts and primordial follicles contain a Balbiani body Proceedings of the National Academy of Sciences of the United States of America. ,vol. 104, pp. 187- 192 ,(2007) , 10.1073/PNAS.0609923104
Trevor N. Stitt, Doreen Drujan, Brian A. Clarke, Frank Panaro, Yekatarina Timofeyva, William O. Kline, Michael Gonzalez, George D. Yancopoulos, David J. Glass, The IGF-1/PI3K/Akt pathway prevents expression of muscle atrophy-induced ubiquitin ligases by inhibiting FOXO transcription factors. Molecular Cell. ,vol. 14, pp. 395- 403 ,(2004) , 10.1016/S1097-2765(04)00211-4
Lylah D. Deady, Wei Shen, Sarah A. Mosure, Allan C. Spradling, Jianjun Sun, Matrix Metalloproteinase 2 Is Required for Ovulation and Corpus Luteum Formation in Drosophila PLOS Genetics. ,vol. 11, pp. e1004989- ,(2015) , 10.1371/JOURNAL.PGEN.1004989