The role of metabolic states in development and disease
作者： Matthew H Sieber , Allan C Spradling
DOI: 10.1016/J.GDE.2017.03.002
关键词: Computational biology 、 Disease 、 Biology 、 Flexibility (engineering) 、 Model system 、 Ecology 、 Animal development 、 Energy metabolism
摘要: During development, cells adopt distinct metabolic strategies to support growth, produce energy, and meet the demands of a mature tissue. Some these states maintain constrained program nutrient utilization, while others providing flexibility as means couple developmental progression with availability. Here we discuss our understanding programs, how they specific aspects animal development. phases rapid proliferation subset programs provide building blocks growth. differentiation, shift unique each Finally, model system, such Drosophila egg can versatile platform discover novel mechanisms controlling programmed in metabolism.
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