Acceleration Effects of Phosphine Ligands on the Rhodium-Catalyzed Dehydrogenative Silylation and Germylation of Unactivated C(sp3)–H Bonds
作者： Masahito Murai , Hirotaka Takeshima , Haruka Morita , Yoichiro Kuninobu , Kazuhiko Takai
关键词: Photochemistry 、 Medicinal chemistry 、 Chemistry 、 Ligand 、 Steric effects 、 Bite angle 、 Desymmetrization 、 Enantioselective synthesis 、 Phosphine 、 Silylation 、 Reactivity (chemistry)
摘要: The current work describes the marked rate of acceleration caused by phosphine ligands on rhodium-catalyzed dehydrogenative silylation and germylation unactivated C(sp3)–H bonds. reactivity was affected steric electronic nature ligands. use bulky electron-rich diphosphine ligand (R)-DTBM-SEGPHOS highly effective to yield products selectively in presence a hydrogen acceptor. An appropriate choice C2-symmetric chiral enables asymmetric via enantioselective desymmetrization bond. unprecedented catalytic bonds with dehydrogenation also examined combination rhodium complex wide bite angle provide corresponding 2,3-dihydrobenzo[b]germoles good yield.
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