Rhodium‐Catalyzed Enantioselective Silylation of Cyclopropyl C−H Bonds
作者： Taegyo Lee , John F. Hartwig
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摘要: Hydrosilyl ethers, generated in situ by the dehydrogenative silylation of cyclopropylmethanols with diethylsilane, undergo asymmetric, intramolecular cyclopropyl C-H bonds high yields and enantiomeric excesses presence a rhodium catalyst derived from precursor bisphosphine (S)-DTBM-SEGPHOS. The resulting enantioenriched oxasilolanes are suitable substrates for Tamao-Fleming oxidation to form cyclopropanols conservation ee value silylation. Preliminary mechanistic data suggest that cleavage is likely be turnover-limiting enantioselectivity-determining step.
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