Therapeutic agents for the treatment of leukemia
作者： Paolo Neviani , Natarajan Muthusamy , Danilo Perrotti , Guido Marcucci , John C. Byrd
DOI:
关键词: Lymphoblastic Leukemia 、 Chronic myelogenous leukemia 、 Medicine 、 Leukemia 、 breakpoint cluster region 、 Blast Crisis 、 Cancer research 、 Refractory
摘要: The invention provides for methods of treating a mammal who has BCR/ABL-mediated leukemia, including chronic myelogenous leukemia (CML), particularly the blast crisis stage CML, Philadelphia-positive acute lymphoblastic (Ph′-ALL), and refractory leukemias. also compounds treatment these leukemias identifying anti-leukemic agents.
lens.org参考文章(27)
Kristine Bjerve Gützkow, Soheil Naderi, Heidi K. Blomhoff, Forskolin-mediated G1 arrest in acute lymphoblastic leukaemia cells: phosphorylated pRB sequesters E2Fs. Journal of Cell Science. ,vol. 115, pp. 1073- 1082 ,(2002) , 10.1242/JCS.115.5.1073
Hinrich Gronemeyer, Michel Lanotte, Gérard Benoit, Marco Gottardis, Compositions and methods for treatment of hyperproliferative diseases ,(2000)
Marc C. Mumby, Brian A. Hemmings, Isao Tawara, Hiroshi Shima, Serdar B. Omay, Hideki Toyoda, Katsumi Deguchi, Masakatsu Nishikawa, Minako Nagao, Expression of the Catalytic and Regulatory Subunits of Protein Phosphatase Type 2A May Be Differentially Modulated during Retinoic Acid-induced Granulocytic Differentiation of HL-60 Cells Cancer Research. ,vol. 54, pp. 4879- 4884 ,(1994)
Koji Teshima, Tomonori Imayoshi, Tsuneo Fujii, Tadashi Mishina, Topical administration of 2-amino-2-(2-(4-octylphenyl)ethyl)propane-1,3-diol ,(1996)
K. Maruno, A. Absood, S. I. Said, Vasoactive intestinal peptide inhibits human small-cell lung cancer proliferation in vitro and in vivo. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 95, pp. 14373- 14378 ,(1998) , 10.1073/PNAS.95.24.14373
Wen Chen, Richard Possemato, K.Thirza Campbell, Courtney A Plattner, David C Pallas, William C Hahn, Identification of specific PP2A complexes involved in human cell transformation. Cancer Cell. ,vol. 5, pp. 127- 136 ,(2004) , 10.1016/S1535-6108(04)00026-1
Nicholas J. Donato, Ji Yuan Wu, Jonathan Stapley, Gary Gallick, Hui Lin, Ralph Arlinghaus, Moshe Talpaz, BCR-ABL independence and LYN kinase overexpression in chronic myelogenous leukemia cells selected for resistance to STI571. Blood. ,vol. 101, pp. 690- 698 ,(2003) , 10.1182/BLOOD.V101.2.690
Estelle Sontag, Protein phosphatase 2A: the Trojan Horse of cellular signaling Cellular Signalling. ,vol. 13, pp. 7- 16 ,(2001) , 10.1016/S0898-6568(00)00123-6
Haskell T. Adler, Ferez S. Nallaseth, Gernot Walter, Douglas C. Tkachuk, HRX Leukemic Fusion Proteins Form a Heterocomplex with the Leukemia-associated Protein SET and Protein Phosphatase 2A Journal of Biological Chemistry. ,vol. 272, pp. 28407- 28414 ,(1997) , 10.1074/JBC.272.45.28407
Thomas Fellner, Daniel H Lackner, Hans Hombauer, Patrick Piribauer, Ingrid Mudrak, Katrin Zaragoza, Claudia Juno, Egon Ogris, A novel and essential mechanism determining specificity and activity of protein phosphatase 2A (PP2A) in vivo Genes & Development. ,vol. 17, pp. 2138- 2150 ,(2003) , 10.1101/GAD.259903