BCR-ABL independence and LYN kinase overexpression in chronic myelogenous leukemia cells selected for resistance to STI571.
作者： Nicholas J. Donato , Ji Yuan Wu , Jonathan Stapley , Gary Gallick , Hui Lin
关键词: K562 cells 、 Tyrosine-kinase inhibitor 、 Imatinib mesylate 、 Proto-oncogene tyrosine-protein kinase Src 、 Cancer research 、 Philadelphia chromosome 、 Chronic myelogenous leukemia 、 Biology 、 Tyrosine kinase 、 LYN
摘要: Clinical studies have shown that the tyrosine kinase inhibitor STI571 effectively controls BCR-ABL–positive chronic myelogenous leukemia (CML). However, disease progression while …
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