Induction of resistance to the Abelson inhibitor STI571 in human leukemic cells through gene amplification.
作者： Philipp le Coutre , Elena Tassi , Marileila Varella-Garcia , Rossella Barni , Luca Mologni
DOI: 10.1182/BLOOD.V95.5.1758.005A41_1758_1766
关键词:
摘要: … /abl positive cell line derived from LAMA84 and resistant to the effects of STI571, designated … lead to such a resistance were investigated. We present evidence that the resistant, newly …
ashpublications.org
bloodjournal.org参考文章(19)
Leukemia cell lines: in vitro models for the study of Philadelphia chromosome-positive leukemia. Leukemia Research. ,vol. 23, pp. 207- 215 ,(1999) , 10.1016/S0145-2126(98)00171-4
R Berthier, F Morle, G Mouchiroud, D Seigneurin, J McGregor, M Prenant, D Leroux, J Starck, P Champelovier, C Micouin, Human chronic myeloid leukemic cell line with positive Philadelphia chromosome exhibits megakaryocytic and erythroid characteristics. Experimental Hematology. ,vol. 15, pp. 822- 832 ,(1987)
Michael W.N. Deininger, John M. Goldman, Nicholas Lydon, Junia V. Melo, The Tyrosine Kinase Inhibitor CGP57148B Selectively Inhibits the Growth of BCR-ABL–Positive Cells Blood. ,vol. 90, pp. 3691- 3698 ,(1997) , 10.1182/BLOOD.V90.9.3691
E Goker, M Waltham, A Kheradpour, T Trippett, M Mazumdar, Y Elisseyeff, B Schnieders, P Steinherz, C Tan, E Berman, Amplification of the dihydrofolate reductase gene is a mechanism of acquired resistance to methotrexate in patients with acute lymphoblastic leukemia and is correlated with p53 gene mutations. Blood. ,vol. 86, pp. 677- 684 ,(1995) , 10.1182/BLOOD.V86.2.677.BLOODJOURNAL862677
A Gaiger, T Henn, E Horth, K Geissler, G Mitterbauer, T Maier-Dobersberger, H Greinix, C Mannhalter, OA Haas, K Lechner, Increase of bcr-abl chimeric mRNA expression in tumor cells of patients with chronic myeloid leukemia precedes disease progression Blood. ,vol. 86, pp. 2371- 2378 ,(1995) , 10.1182/BLOOD.V86.6.2371.BLOODJOURNAL8662371
Brian J. Druker, Elisabeth Buchdunger, Thomas Meyer, Marcel Müller, Nicholas B. Lydon, Helmut Mett, Jürg Zimmermann, Inhibition of the Abl Protein-Tyrosine Kinase in Vitro and in Vivo by a 2-Phenylaminopyrimidine Derivative Cancer Research. ,vol. 56, pp. 100- 104 ,(1996)
Nora Heisterkamp, Guido Jenster, Joanne ten Hoeve, Daniel Zovich, Paul K. Pattengale, John Groffen, Acute leukaemia in bcr/abl transgenic mice Nature. ,vol. 344, pp. 251- 253 ,(1990) , 10.1038/344251A0
Giuliana Pelicci, Luisa Lanfrancone, Francesco Grignani, Jane McGlade, Federica Cavallo, Guido Forni, Ildo Nicoletti, Fausto Grignani, Tony Pawson, Pier Giuseppe Pelicci, A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction. Cell. ,vol. 70, pp. 93- 104 ,(1992) , 10.1016/0092-8674(92)90536-L
Brian J. Druker, Shu Tamura, Elisabeth Buchdunger, Sayuri Ohno, Gerald M. Segal, Shane Fanning, Jürg Zimmermann, Nicholas B. Lydon, Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells. Nature Medicine. ,vol. 2, pp. 561- 566 ,(1996) , 10.1038/NM0596-561
G. Daley, R. Van Etten, D Baltimore, Induction of chronic myelogenous leukemia in mice by the P210bcr/abl gene of the Philadelphia chromosome Science. ,vol. 247, pp. 824- 830 ,(1990) , 10.1126/SCIENCE.2406902