A short update on cancer chemoresistance

摘要: Chemotherapeutic interventions in cancer patients are limited by the appearance of chemoresistance. For instance, advanced lung and ovarian relapse invariably after few cycles platinum-based chemotherapy. Disseminated tumors characterized genetic instability/heterogeneity, thus containing or generating a repertoire resistant subpopulations. At cellular level, altered drug uptake, efflux, metabolization, as well modifications targets, increased repair, decreased cell death complement perfusion adverse hypoxic/acidic extracellular conditions at tumor level retaining viability. Similarly, targeted therapy is rendered ineffective mutations specific target protein within months years administration. Assessment expression profiles cells revealed extensive changes numerous pathways affecting hundreds genes. Therefore, reversal resistance will require individual mediators combination several drugs, targeting critical components to provide new therapeutic options.