Relationship of Cellular Glutathione to the Cytotoxicity and Resistance of Seven Platinum Compounds

摘要: Abstract The role of glutathione (GSH) in the effectiveness and resistance to 7 platinum compounds (5 Pt(II) 2 Pt(IV) drugs] was evaluated a 8.6-fold cisplatin (CDDP)-resistant human small cell lung cancer line (GLC4/CDDP), parent GLC4 line, 3.7-fold CDDP-resistant embryonal carcinoma (Tera-CP), Tera (NTera2/D1). Resistance factors for both lines were determined after continuous incubation (4 days) with CDDP. Continuous other studied drugs revealed complete cross-resistance carboplatin (CBDCA) zeniplatin but less enloplatin (ENLO) iproplatin models. Tetraplatin lobaplatin showed, respectively, partial GLC4/CDDP no Tera-CP. GSH level, not S-transferase activity, 4 correlated drug concentrations inhibiting survival by 50% (r = 0.86, P Reduction CDDP BSO known occur identical cellular levels higher Pt-DNA binding GLC4/CDDP. However, pretreatment followed h ENLO increased while remained unchanged. In conclusion, reflected sensitivity platinum-containing drugs. since involvement differed between models various drugs, effect modulation unpredictable. costs publication this article defrayed part payment page charges. This must therefore be hereby marked advertisement accordance 18 U.S.C. Section 1734 solely indicate fact.