Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells.

作者: Brian J. Druker , Shu Tamura , Elisabeth Buchdunger , Sayuri Ohno , Gerald M. Segal

DOI: 10.1038/NM0596-561

关键词:

摘要: … containing the BcrAbl fusion protein. Cellular proliferation and tumor formation by Bcr-Abl-… –98% decrease in the number of bcr-abl colonies formed but no inhibition of normal colony …

参考文章(51)
Matulonis U, Griffin Jd, Salgia R, Okuda K, Druker B, Interleukin-3 and p210 BCR/ABL activate both unique and overlapping pathways of signal transduction in a factor-dependent myeloid cell line. Experimental Hematology. ,vol. 21, pp. 1460- 1466 ,(1993)
HM Kantarjian, A Deisseroth, R Kurzrock, Z Estrov, M Talpaz, Chronic myelogenous leukemia: a concise update Blood. ,vol. 82, pp. 691- 703 ,(1993) , 10.1182/BLOOD.V82.3.691.691
A Bedi, BA Zehnbauer, JP Barber, SJ Sharkis, RJ Jones, Inhibition of apoptosis by BCR-ABL in chronic myeloid leukemia Blood. ,vol. 83, pp. 2038- 2044 ,(1994) , 10.1182/BLOOD.V83.8.2038.2038
Sante Tura, Michele Baccarani, Eliana Zuffa, Domenico Russo, Renato Fanin, Alfonso Zaccaria, Mauro Fiacchini, None, Interferon alfa-2a as compared with conventional chemotherapy for the treatment of chronic myeloid leukemia. The New England Journal of Medicine. ,vol. 330, pp. 820- 825 ,(1994) , 10.1056/NEJM199403243301204
Brian J. Druker, Conor Heaney, James D. Griffin, John R. Hagopian, Keiko Okuda, Tsukasa Oda, Crkl is the major tyrosine-phosphorylated protein in neutrophils from patients with chronic myelogenous leukemia. Journal of Biological Chemistry. ,vol. 269, pp. 22925- 22928 ,(1994) , 10.1016/S0021-9258(17)31596-X
P. C. Nowell, A minute chromosome in human chronic granulocytic leukemia Science. ,vol. 132, pp. 1497- ,(1960)
T. Matsuguchi, R. Salgia, M. Hallek, M. Eder, B. Druker, T.J. Ernst, J.D. Griffin, Shc phosphorylation in myeloid cells is regulated by granulocyte macrophage colony-stimulating factor, interleukin-3, and steel factor and is constitutively increased by p210BCR/ABL. Journal of Biological Chemistry. ,vol. 269, pp. 5016- 5021 ,(1994) , 10.1016/S0021-9258(17)37647-0
P Martiat, P Lewalle, AS Taj, M Philippe, Y Larondelle, JL Vaerman, C Wildmann, JM Goldman, JL Michaux, Retrovirally transduced antisense sequences stably suppress P210BCR-ABL expression and inhibit the proliferation of BCR/ABL-containing cell lines. Blood. ,vol. 81, pp. 502- 509 ,(1993) , 10.1182/BLOOD.V81.2.502.502