Shc phosphorylation in myeloid cells is regulated by granulocyte macrophage colony-stimulating factor, interleukin-3, and steel factor and is constitutively increased by p210BCR/ABL.

摘要: Granulocyte macrophage colony-stimulating factor, interleukin-3, and steel factor induce proliferation of hematopoietic cells through binding to specific, high affinity, cell surface receptors. However, little is known about post-receptor signal transduction pathways. Here we report that an SH2 domain containing protein previously implicated in the activation p21ras, Shc, transiently tyrosine phosphorylated myeloid after stimulation with granulocyte or factor. Also, Shc was found be constitutively lines made independent by expression p210BCR/ABL. A Shc-associated 140-kDa identified, which on residues cytokine These findings suggest could play important role a pathway, leads cells.