Phosphatidylinositol 3-kinase, Phosphoinositides and Apoptosis

Targets of B-cell antigen receptor signaling: the phosphatidylinositol 3-kinase/Akt/glycogen synthase kinase-3 signaling pathway and the Rap1 GTPase. Immunological Reviews. ,vol. 176, pp. 47- 68 ,(2000) , 10.1034/J.1600-065X.2000.00601.X

T. Kinoshita, T. Yokota, K. Arai, A. Miyajima, Suppression of apoptotic death in hematopoietic cells by signalling through the IL-3/GM-CSF receptors. The EMBO Journal. ,vol. 14, pp. 266- 275 ,(1995) , 10.1002/J.1460-2075.1995.TB07000.X

S Cockcroft, G M H Thomas, Inositol-lipid-specific phospholipase C isoenzymes and their differential regulation by receptors. Biochemical Journal. ,vol. 288, pp. 1- 14 ,(1992) , 10.1042/BJ2880001

R Aebersold, I van Oostveen, M R Gold, D Bowtell, T M Saxton, B cell antigen receptor cross-linking induces phosphorylation of the p21ras oncoprotein activators SHC and mSOS1 as well as assembly of complexes containing SHC, GRB-2, mSOS1, and a 145-kDa tyrosine-phosphorylated protein. Journal of Immunology. ,vol. 153, pp. 623- 636 ,(1994)

Antonio D. Cristofano, Barbara Pesce, Carlos Cordon-Cardo, Pier P. Pandolfi, Pten is essential for embryonic development and tumour suppression. Nature Genetics. ,vol. 19, pp. 348- 355 ,(1998) , 10.1038/1235

J. Borst, L. Smit, A. M. M. De Vries-Smits, J. L. Bos, B cell antigen receptor stimulation induces formation of a Shc-Grb2 complex containing multiple tyrosine-phosphorylated proteins. Journal of Biological Chemistry. ,vol. 269, pp. 20209- 20212 ,(1994) , 10.1016/S0021-9258(17)31975-0

J. Sayos, C. Wu, M. Morra, N. Wang, X. Zhang, D. Allen, S. van Schaik, L. Notarangelo, R. Geha, M. G. Roncarolo, H. Oettgen, J. E. De Vries, G. Aversa, C. Terhorst, The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM Nature. ,vol. 395, pp. 462- 469 ,(1998) , 10.1038/26683

J G Monroe, A Norvell, L Mandik, Engagement of the antigen-receptor on immature murine B lymphocytes results in death by apoptosis. Journal of Immunology. ,vol. 154, pp. 4404- 4413 ,(1995)

H-J. Su Huang, Webster K. Cavenee, Frank B. Furnari, The Phosphoinositol Phosphatase Activity of PTEN Mediates a Serum-sensitive G1 Growth Arrest in Glioma Cells Cancer Research. ,vol. 58, pp. 5002- 5008 ,(1998)

Edward A. Clark, Svetlana P. Sidorenko, Svitlana V. Mikhalap, Anna G. Berdova, Larisa M. Shlapatska, Che-Leung Law, CDw150 associates with src-homology 2-containing inositol phosphatase and modulates CD95-mediated apoptosis. Journal of Immunology. ,vol. 162, pp. 5719- 5727 ,(1999)