Regulation of the production and function of granulocytes and monocytes.

摘要: The bone marrow responds to infection by rapidly producing mature granulocytes and monocytes from a small pool of committed progenitor cells under the influence heterogeneous family glycoproteins termed colony-stimulating factors (CSFs). There are at least four major CSFs (IL-3, GM-, G-, M-CSF) which structurally distinct but have great deal functional overlap. humoral signals regulate production generated peripheral sites through activation local macrophages T lymphocytes invading pathogen. monokines IL-1 TNF most likely involved in stimulating CSF secretion accessory tissue as well microenvironment, although functions produced these two organ compartments is distinct. secreted endothelial fibroblasts serve stimulate proliferation differentiation myeloid cells, while present areas cell function. dual ability both function represents novel mechanism for coordinated host response infection.