Treatment of aplastic anemia in children with recombinant human granulocyte colony-stimulating factor.
作者： S Kojima , M Fukuda , Y Miyajima , T Matsuyama , K Horibe
DOI: 10.1182/BLOOD.V77.5.937.937
关键词:
摘要: Twenty children (aged 1 to 17 years) with severe or moderate aplastic anemia were treated recombinant human granulocyte colony- stimulating factor (rhG-CSF) at a dose of 400 micrograms/m2 per day administered as 30-minute intravenous (IV) infusion daily for 2 weeks. This treatment increased the neutrophil counts (2.7- 28.0- fold) in 12 20 patients. Increasing doses (800 1,200 day) five patients who had not responded initial dose, and three showed an increase count. Differential bone marrow (BM) aspirates myeloid/erythroid ratio. The response was transient, however, count returned baseline within 10 days discontinuing treatment. No toxicity attributable rhG-CSF observed. results suggest that this agent is effective granulopoiesis anemia. Our study also indicates will be particularly useful managing complicated by bacterial fungal infection.
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