Gastrointestinal stromal tumors and second primary malignancies before and after the introduction of imatinib mesylate

摘要: Gastrointestinal stromal tumor (GIST) is the most common mesenchymal malignancy of gastrointestinal tract. GISTs may coexist with different types cancer, either synchronous or metachronous (1). Most develop in a sporadic fashion, but familial occurrence, such as neurofibromatosis and Carney-triad, has also been reported (2). The overall frequency second tumors series varied from 4.5% to 33%. frequent GIST-associated cancers were carcinomas (47%), lymphoma/leukemia (7%), prostate (9%), breast kidney (6%), lung (5%), female genital tract carcinoid (3%), soft tissue bone sarcomas malignant melanoma (2%) seminoma (1%) (1,3-5).