Amplification in DNA Copy Numbers as a Mechanism of Acquired Drug Resistance
作者： M. Jim Yen , Ie-Ming Shih , Victor E. Velculescu , Tian-Li Wang
DOI: 10.1007/978-1-59745-035-5_28
关键词:
摘要: Resistance to chemotherapeutic agents represents a chief cause of mortality in cancer patients with advanced disease. Gene amplification has been shown be one the molecular mechanisms for tumors escape effect drugs. The and subsequent overexpression chemoresistant gene product are likely results tumor cell clonal expansion under selective pressure agents. In past few decades, researchers have correlated several target genes drug resistance status vitro culture models. Although it is possible widespread mechanismof chemore-sistance patients, only well-studied examples presently available. Therefore, future application new advances genetic technology holds promise discovery novel amplified genes, which may significantly affect our understanding how become as well provide platform customized treatment patients.
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