Novel conjugates of cc-1065 analogs and bifunctional linkers
作者： Henri Johannes Spijker , Rudy Gerardus Elisabeth Coumans , Patrick Henry Beusker , Wiro Michael Petrus Bernardus Menge , Ronald Christiaan Elgersma
DOI:
关键词: Chemistry 、 Combinatorial chemistry 、 Bifunctional 、 Conjugate 、 DNA 、 Stereochemistry
摘要: This invention relates to novel analogs of the DNA-alkylating agent CC-1065 and their conjugates. Furthermore this concerns intermediates for preparation said agents The conjugates are designed release (multiple) payload after one or more activation steps and/or at a rate time span controlled by conjugate in order selectively deliver controllably DNA alkylating agents. agents, conjugates, can be used treat an illness that is characterized undesired (cell) proliferation. As example, may tumor.
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