Hydrophilic self-immolative linkers and conjugates thereof

摘要: The present disclosure provides compounds with a hydrophilic self-immolative linker, which is cleavable under appropriate conditions and incorporates group to provide better solubility of the compound. comprise drug moiety, targeting moiety capable selected cell population, linker contains an acyl unit, optional spacer unit for providing distance between peptide can be conditions, second or cyclization self-elimination linker.