Engineered antibody drug conjugates
作者： Charlotte Mcdonagh , Paul Carter
DOI:
关键词:
摘要: The present invention provides ligand drug conjugates for targeted delivery of drugs. have potent cytotoxic activity against antigen-specific targets, as compared with intact antibody conjugates.
aacrjournals.org 
google.it 参考文章(6)
Lewis Gazzard, Paul J. Carter, Caspase activated prodrugs therapy ,(2001)
Gail Urlaub, Pamela J. Mitchell, Emmanuel Kas, Lawrence A. Chasin, Vicky L. Funanage, T. Timothy Myoda, Joyce Hamlin, Effect of gamma rays at the dihydrofolate reductase locus: deletions and inversions Somatic Cell and Molecular Genetics. ,vol. 12, pp. 555- 566 ,(1986) , 10.1007/BF01671941
Frederick R. Taylor, Holly L. Prentice, Ellen A. Garber, Hans A. Fajardo, Elena Vasilyeva, R. Blake Pepinsky, Suppression of sodium dodecyl sulfate-polyacrylamide gel electrophoresis sample preparation artifacts for analysis of IgG4 half-antibody. Analytical Biochemistry. ,vol. 353, pp. 204- 208 ,(2006) , 10.1016/J.AB.2006.02.022
May S. Kung Sutherland, Russell J. Sanderson, Kristine A. Gordon, Jamie Andreyka, Charles G. Cerveny, Changpu Yu, Timothy S. Lewis, Damon L. Meyer, Roger F. Zabinski, Svetlana O. Doronina, Peter D. Senter, Che-Leung Law, Alan F. Wahl, Lysosomal Trafficking and Cysteine Protease Metabolism Confer Target-specific Cytotoxicity by Peptide-linked Anti-CD30-Auristatin Conjugates Journal of Biological Chemistry. ,vol. 281, pp. 10540- 10547 ,(2006) , 10.1074/JBC.M510026200
C. F. McDonagh, E. Turcott, L. Westendorf, J. B. Webster, S. C. Alley, K. Kim, J. Andreyka, I. Stone, K. J. Hamblett, J. A. Francisco, P. Carter, Engineered antibody–drug conjugates with defined sites and stoichiometries of drug attachment Protein Engineering Design & Selection. ,vol. 19, pp. 299- 307 ,(2006) , 10.1093/PROTEIN/GZL013
Uwe Bechtold, Jens Otterbach, Rolf Eymann, Ralf Pasternack, Hans-Lothar Fuchsbauer, Method for transglutaminase-catalyzed coupling of protein or peptide to a support ,(1998)