Mutated immunoglobulin-binding polypeptides
作者： Göran Baurén , Gustav Rodrigo , Tomas Björkman , Mats Ander
DOI:
关键词: Biochemistry 、 Protein A 、 Protein Z 、 Glutamine 、 Mutant 、 Amino acid 、 Immunoglobulin binding 、 Molecular biology 、 Biology 、 Residue (chemistry) 、 Asparagine
摘要: The invention discloses a polypeptide with improved alkaline stability, which comprises mutant of B or C domain Staphylococcus Protein A (SpA), as specified by SEQ ID NO 1 2, Z, 3, wherein at least the glutamine residue position 9 has been mutated to an amino acid other than asparagine. also multimers said polypeptide, well separation matrices comprising polypeptides.
lens.org 参考文章(165)
Young Gyu Cho, Woon Young Lee, Woo Ick Jang, Hye Jeong Shin, Human interleukin-1 receptor antagonist—hybrid Fc fusion protein ,(2011)
Yasunori Kihira, Sachiko Aiba, Use of immunoglogulin-binding artificial proteins as molecular weight markers ,(1995)
Masahide Tone, Ramachandran Murali, Hongtao Zhang, Mark I. Greene, Xiaomin Song, Antigen-binding proteins comprising recombinant protein scaffolds ,(2010)
Alex Eon-Duval, Alain Lamproye, Process for the purification of fc-fusion proteins ,(2007)
Joerg Thomas Regula, Frank Herting, Christian Klein, Matthias Rueth, Kay Gunnar Stubenrauch, Harald Duerr, Bispecific anti-vegf/anti-ang-2 antibodies and their use in the treatment of ocular vascular diseases ,(2013)
Takashi Ishihara, Method for purifying protein using amino acid ,(2011)
Gregory S. Blank, Protein purification by Protein A chromatography ,(1997)
Tarik Dabdoubi, Catherine Prades, Béatrice Cameron, Francis Blanche, Frédérique Dol-Gleizes, Pierre Fons, Jean-Pascal Herault, Robo1-fc fusion protein and use thereof for treating tumours ,(2011)
Robert Sidong Qiu, Andrew G. Plaut, Jiazhou Qiu, Methods and compositions for diagnosis of iga-and igm-mediated kidney diseases ,(2006)
Yoshiyuki Nakano, Keita Iguchi, Dai Murata, Shinichi Yoshida, Junya Akagi, Masayuki Takano, Protein having affinity for immunoglobulin, and immunoglobulin-binding affinity ligand ,(2010)